Itraconazole loaded ethosomes were prepared and characterized by vesicular shape, vesicular size, entrapment efficiency. Ethosomal gel were prepared and. J Cosmet Dermatol. Aug doi: /jocd [Epub ahead of print]. Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis. J Liposome Res. Nov doi: / [ Epub ahead of print]. Transdermal ethosomal gel nanocarriers; a promising.

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These benefits may lead to wthosomal good compliance of patient, lower cost production, and less of the dose-related side effects [ 55 ]. Receptor compartment was filled by phosphate buffer solution pH 7.

Gels should not be too acidic or alkaline because they can irritate the skin. A bioavailability study was performed by grouping rats into three groups.

This phenomenon was caused by the high content of water from the gel. In this study, QC-loaded ethosomes was incorporated into a gel dosage form. Carvedilol-loaded ethosomes were characterized by microscopic examinations followed by other in-vitro assessments. According to the in vitro penetration study, the diffusion flux of quercetin from the ethosomal and non-ethosomal gels were The optimized formulation did not cause any irritation to the skin since the pH of etnosomal was in the pH range of skin.


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However, QC has low oral bioavailability [ 2 ]. Diffusion flux for each dosage form was shown in Figure 5. Keywords Ethosomal gel, Itraconazole, Basal cell carcinoma, Antiproliferative study, skin irritation study.

A cycling test for six cycles was also performed.

Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis.

When QC administered orally, as mentioned above, it would be metabolized immediately. Based on the stability test results, there were not any changes in colour or odour for EG for all temperature storage. However, pH of all gels was still around 4. These results showed that QC given transdermally could etbosomal greater bioavailability compared to the oral administration.

Cutaneous candidiasis is the infection caused by Candida albicans or other Candida species. A previous study on QC ethosomes by Park et al. They tend to have a pseudoplastic thixotropic rheology. The results showed that developed formulation could be promising one in the topical delivery of clove oil for the treatment of cutaneous candidiasis.

Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis.

Furthermore, ethosomes can entrap many kinds of drugs, not only hydrophilic drugs such as bupropion hydrochloride [ 18 ] and salbutamol sulfate [ 19 ], but also hydrophobic drugs like piroxicam [ 20 ], carvedilol [ 21 ], finasteride [ 22 ] and clotrimazole [ 23 ]. Email this article Login required. Pharmaceutica Analytica Acta Open Access. However, it has low oral bioavailability and penetration through the skin. Ethosomal gel were prepared by using Carbopol.


Naproxen is an anti-inflammatory drug used in the treatment of inflammation, fever, gout and arthritis It has many side effects like gastric irritation, heat burn and nausea when taken orally. Ethanol increases the elasticity ethosmal flexibility of ethosomes so that it can penetrate through the stratum corneum freely [ 141530 ].

Ethosomes of ethosojal oil was formulated by using varying concentrations of soyaphosphotidyl choline and ethanol, and later, it was incorporated into carbapol base gels to form ethosomal gel.

The receptor compartment was immediately replaced with an equal volume of fresh medium. Ethogels were subjected to physicochemical characterization, compatibility, and in-vitro drug release studies. Ravishankar Shukla University, Raipur, G. Stability studies revealed no noticeable changes in drug release profile occurred.

Based on the pH measurement during the 12 w of storage, pH of all gels was in the range of the skin pH. Additionally, viscosity and rheological properties using Brookfield viscometer Brookfield, USA were observed at the first and twelfth week.

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